Synergistic killing of human leukaemic lymphoblasts by glucocorticoids and cytosine arabinoside
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چکیده
منابع مشابه
Mechanism of synergistic cell killing when methotrexate precedes cytosine arabinoside: study of L1210 and human leukemic cells.
Synergistic killing of L1210 cells occurs when methotrexate (MTX) is administered just before 1-beta-D-arabinofuranosylcytosine (Ara-C). This pehnomenon is dependent upon both the dose and time of exposure to MTX. Such increased killing of cells can be explained by the enhanced intracellular accumulation of Ara-C in cells exposed to MTX. This enhancement of Ara-C entry into cells was only obser...
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The combined treatment of cultures of human embryonic lung cells with herpes simplex virus type 2 and cytosine arabinoside produced a significantly increased number of cells containing multiple chromatid and chromosome breaks. The incidence of such cells was found to be approximately two and one half times greater than the additive effects of virus and cytosine arabinoside induced separately an...
متن کاملIncreased accumulation of cytosine arabinoside in human leukemic cells and enhancement of its cell-killing activity by uridine.
The effects of uridine(UR) on the cell-killing activity of cytosine arabinoside(ara-C) against human leukemic cells, MOLT-4, and on ara-C accumulation in cells were studied. The 50% lethal dose(LD50) of ara-C as determined by clonogenic assay was decreased to 5.0 x 10(-8) mol from 9.0 x 10(-7) mol after 3 days exposure to 10(-3) mol of UR. The accumulation of 3H-ara-C at 24 and 48 h was signifi...
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We investigated the efficacy of dexamethasone plus diclofenac eye drops as prophylaxis for conjunctivitis induced by high-dose (HD) cytarabine (Ara-C). Sixty patients were randomized to receive either dexamethasone (group A, n=29) or dexamethasone plus diclofenac (group B, n=31). Conjunctivitis was experienced by 13/29 (45%) patients in group A, and 4/31 (13%) patients in group B (p<or=0.009). ...
متن کاملAlteration of antibody synthesis in the rat by cytosine arabinoside.
cells (4). Complete suppression of the secondary response to tetanus toxoid also was achieved in the rabbit (18). The pri mary and secondary responses in patients with neoplasia were inhibited completely, but often temporarily, by injections or infusions of ara-C (21). A high dose of ara-C, given 1 hour before injection of antigen, has been reported to produce anti body titers exceeding those o...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1983
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1983.103